Cytadren
Cytadren is not an anabolic/androgenic steroid. Since it is a steroidbiosynthesial inhibitor it belongs to the group of sex hormones. Cytadren inhibits the build up of androgens, estrogens, and the suprarenal cortical hormones (glucocorticoids and mineralocorticoids).
Let us first take a look at the latter two points since they explain why athletes are interested in this compound. Cytadren has a highly anti estrogenic effect since, on the one hand, it inhibits the bodies own estrogen production and, on the other hand, it obviates the conversion of androgens into estrogens. This is especially encouraging since it helps to keep the estrogen level of bodybuilders low. The second highly interesting point is that Cytadren prohibits the build up of adrenocortical hormones. It obviates the production of endogenous cortisone like no other compound by inhibiting the conversion of cholesterol into cortisone. For this reason, Cytadren, in school medicine, is used for the treatment of Cushings syndrome, a hyper function of the adrenal glands which causes the body to overproduce cortisone. Consequently, it reduces the cortisone level, which has several advantages for the athlete. Cortisone is a catabolic hormone and catabolic is the exact opposite of anabolic. Cortisone prevents the protein synthesis in the muscle cell, resulting in a muscular atrophy by breaking down amino acids in the muscle cell.
The human body constantly releases cortisone and reacts to stress situations such as intense training by increasing its cortisone release. Natural bodybuilders, therefore, after a short time, experience a stagnation in their development since the release of the bodies cortisone is higher than the anabolic effect of working out. The more advanced the athlete and the harder his workout, the more his cortisone level will increase.
If the release of cortisone can be successfully obviated or at least considerably reduced the ratio of anabolic hormones to catabolic hormones in the body shifts in favor of the former. This results in an increase in muscle mass and body strength. And Cytadren achieves exactly these results; however, there is one problem. Cytadren reduces the cortisone level so effectively that the body tries to balance this by hypophysially producing more ACTH (adenocorticotropic hormone), thus stimulating the secretion of cortisone by the adrenal glands. Thus in school medicine, when treating Cushings syndrome, a low dose of oral hydrocortisone is used to prevent the hypophysis from producing ACTH. The dose is so low that the cortisone level in the blood does not rise substantially. And this is exactly the problem. Cytadren reduces the cortisone level which the body balances by producing ACTH, thus neutralizing the effect of Cytadren. If exogenous hydrocortisone is taken no ACTH is produced; however, this also reduces the effect of Cytadren. It is therefore necessary to find an administration schedule that prevents or delays the bodies own production of ACTH. Since the body does not show abrupt reactions when the cortisone level is lowered by the intake of Cytadren, the compound must be taken over several days before the body begins reacting. If Cytadren is only taken for a period of two days and then discontinued for two entire days, it seems logical that the body will not have enough time to react accordingly, thus interrupting the production of ACTH in the hypophysis. Similar to Clenbuterol, alternating administration schedule with two days of administration and two days of abstinence is created.
Another problem needs to be solved since Cytadren, as mentioned earlier, inhibits the bodies own production of androgen. Cytadren, therefore, should not be used by natural bodybuilders. The solution to this problem is to take a long term effective testosterone such as Testoviron Depot simultaneously. Testoviron Depot, for example, can be considered as one such possible compound.
As for the question of dosage, we have arrived at a very interesting point. In school medicine the dosage for the treatment of Cushings syndrome is between 2 and 7 tablets per day. Since not enough athletes have used this compound so far, we do not have enough experimental data. Due to the fact that the cortisone level of athletes is not as high as in persons who suffer from a hyperfunction of the adrenal glands, it is probable that lower dosages are sufficient. From what we have heard so far. 2-4 tablets of 250 mg each per day seems to be an appropriate dose. The tablets are always taken individually, in regular intervals throughout the day, and taken best during meals. It is important to begin the intake by "sneaking in," which means that you begin by taking only one tablet and then slowly and evenly increasing the dosage until the respective maximum dosage is reached. How long should it be taken? This question is difficult to answer but, considering that the body can sometimes increase the production of ACTH, it is advised that the compound is not used longer than 4-6 weeks. (We must also consider potential side effects, which we will discuss in a minute.) Another interesting aspect: Cytadren is (as of yet) not on any doping list. We have heard from reliable informants that a combination of Cytadren, growth hormones, and a low quantity of injectable testosterone is the new hit among athletes of any field, since it allows the athlete to pass any doping test.
Thus the side effects of Cytadren need to be looked at and they are, unfortunately, numerous and /sometimes very severe. The most common side effects are fatigue and dizziness. Lack of concentration, restlessness, depression, apathy, and sleeping disorder are less common but possible. Even rarer and mostly depending on the doses are nausea, vomiting, gastrointestinal pain, diarrhea, and headaches. A possible rash and the already-mentioned fatigue and dizziness are usually initial symptoms and these can be minimized by taking slowly increasing dosages, or they may simply disappear. The package insert of Ciba-Geigy GmbH Germany also states that in some cases there is an inadequate thyroid function which requires treatment. It is therefore recommended that the thyroid gland be supervised by a physician during intake of Cytadren. Another problem that can occur is liver disease. Cases of reduced counts of the white blood cells, the blood platelets, and even of all blood cells have been reported. Those who plan to try Cytadren should carefully read the package insert. It has been our experience that athletes, due to the reduced cortisone level, complain about joint pain and are also exposed to a higher risk of getting injured. There is no question that Cytadren is effective when taken according to the two-day alternating administration schedule of Cytadren, however, the athlete should carefully consider the cost/benefit factor prior to taking the compound.
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